• Passa alla navigazione primaria
  • Passa al contenuto principale
  • Passa alla barra laterale primaria
  • Passa al piè di pagina

Cerca nel sito

  • Chi siamo
    • Governance
    • Team of Facilities
  • Dove siamo
  • Contattaci
  • Per te paziente
  • EN
  • IT
gemelli generator logo

GemelliGenerator

  • Facilities
    • Epidemiology & Biostatistics
    • Data Collection
    • Bioinformatics
    • Real World Data
  • Servizi
  • Ricerca
    • Progetti Europei
    • Progetti
    • Pubblicazioni
  • Opportunità
    • Bandi di concorso
    • Formazione
  • Network & Partners
  • News ed Eventi
Home / Progetti / The IMPROVEMENT study

International Multicenter Prospective, Non-competitive, Observational study to Validate and Optimize Prediction Kinetic Models of 90-day and 1-year Allograft Failure after Liver Transplantation

Principal Investigator:

  • PI, Alfonso W. Avolio, MD, General Surgery and Liver Transplant Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Catholic University of Rome, L.go A.Gemelli, 8, Rome Italy – 00168.
  • Co-PI, Vatche G. Agopian, MD, Liver Cancer Center – General Surgery and Liver Transplant Unit, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095.

Ricercatori coinvolti:

Steering Committee

Vatche Agopian (US), VAgopian@mednet.ucla.edu
Alfonso Avolio (IT), alfonso.avolio@unicatt.it
Patrizia Burra (IT), burra@unipd.it
Kris Croome (US), croome.kristopher@mayo.edu
Martin De Santibanes (Argentina), martin.desantibanes@hospitalitaliano.org.ar
Hiroto Egawa (Japan), egawa.hiroto@twmu.ac.jp
Constantino Fondevila (Spain), constantino.fondevila@salud.madrid.org
Zhiyong Guo (China), rockyucsf1981@126.com
Quirino Lai (IT), quirino.lai@uniroma1.it
Paulo Martins (US), Paulo.Martins@umassmemorial.org
Gabriel Oniscu (UK), gabriel.oniscu@ed.ac.uk
Wojtek Polak (NE), w.polak@erasmusmc.nl
Cristiano Quintini (US), quintic@ccf.org
Mohamed Rela (India), mohamedrela@gmail.com
Gonzalo Sapisochin (Canada), gonzalo.sapisochin@uhn.ca
Umberto Cillo (IT), cillo@unipd.it

Data Collection & Management

Tina Pasciuto (IT),  tina.pasciuto@policlinicogemelli.it
Research Core Facility DATA COLLECTION G STeP (IT), datacollection.gstep@policlinicogemelli.it

Obiettivo:

The IMPROVEMENT study is an observational and non-competitive study aimed to validate and optimize prediction kinetic models of 90-day and 1-year allograft failure after liver transplantation.
It includes a prospective cohort, reserved for high-volume Centers (>65 transplants per year), and a retrospective one reserved for intermediate and low-volume Centers (<65 transplants per year). High-volume Centers may participate in prospective and retrospective enrollment.
Standard Deceased Donors grafts, Extended Criteria grafts, Cardiac Death Donor grafts, and Living Donor grafts will be included according to the practice of Centers. Each Center is invited to enroll a fixed number of consecutive grafts (50 for the prospective cohort and 75 for the retrospective cohort). Notably, the histological assessment of graft steatosis obtained after graft reperfusion is desirable (prospective cohort). Furthermore, patients will be prospectively evaluated by frailty, nutritional, and sarcopenia assessments to disentangle the indication/contraindication to re-transplant. The degree of cardiac dysfunction, renal failure, respiratory failure, abdominal and lung infection, sepsis, and septic shock will be also investigated as well as technical issues potentially leading to allograft failure.

In this repository, the study protocol with annexes, the approval by the Ethics Committee of the promoting Center, a set of slides, the FAQs and the articles inherent to the study are available for download.

For information alfonso.avolio@unicatt.it or VAgopian@mednet.ucla.edu

Barra laterale primaria

Search

Le nostre facilities

  • Epidemiology & Biostatistics
  • Data Collection
  • Bioinformatics
  • Real World Data

Ultime da Gemelli Generator

  • 26/07/2022
    Azimuth, un percorso di digital health integrato per i pazienti con insufficienza cardiaca
  • 29/11/2021Eventi
    IL RUOLO DELLA BIOINFORMATICA NELLA RICERCA CLINICA: EVIDENZE E NUOVE PROSPETTIVE.
  • News
    25/10/2021Ricerca
    L'intelligenza artificiale e la bellezza della guarigione
  • Eventi
    09/09/2021Video
    Sanità. L'uso dell'Intelligenza artificiale nei servizi sanitari. Intervista al Prof. Vincenzo Valentini

Formazione

Scopri i nostri corsi

Hai bisogno di aiuto?

Saremo lieti di fornirti tutte le informazioni e il supporto necessario per avere la migliore esperienza possibile con Gemelli GENERATOR

Contattaci ora

Footer

  • Facilities
    • Epidemiology & Biostatistics
    • Data Collection
    • Bioinformatics
    • Real World Data
  • Servizi
  • Ricerca
    • Progetti Europei
    • Progetti
    • Pubblicazioni
  • Opportunità
    • Bandi di concorso
    • Formazione
  • Network & Partners
  • News ed Eventi
  • Chi siamo
    • Governance
    • Team of Facilities
  • Dove siamo
  • Contattaci
  • Per te paziente

Informativa sulla Privacy

Cookie Policy

Avvertenze

Condizioni di utilizzo


Sostienici
gemelli generator footer
logo facebook
logo twitter
logo youtube
logo linkedin
logo policlinico gemelli
logo cattolica

© 2020 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Codice Fiscale e P.IVA n. 13109681000

 

Sede Legale Largo Francesco Vito 1, 00168 Roma
Sede Operativa Largo Agostino Gemelli 8, 00168 Roma
Tutti i diritti riservati / All Rights Reserved – Credits