Liver involvement in COVID subjects (LiCO). Observational study for understanding clinical phenotype and of biomarkers for progression of fibrosis and liver disease in subjects with Sars-COV2 infection. An omic strategy for personalized approach.

Target:

The aim of the study is to associate survival with the presence or absence of liver damage defined as hypertransaminasemia (ALT > 1.5 x UNL). The hypothesis underlying the present study is that the severity of COVID is determined by factors modulating the cellular response to oxidative stress and that the transition of the adaptive response to the development of damage can be recognised by a combination of markers reflecting the balance between pro- and anti-inflammatory responses to oxidative stress with the liver as the main organ involved.