{"id":4967,"date":"2022-04-04T14:33:03","date_gmt":"2022-04-04T12:33:03","guid":{"rendered":"http:\/\/www.gemelligenerator.it\/?post_type=kf_gem_progetto&#038;p=4967"},"modified":"2022-09-29T13:33:58","modified_gmt":"2022-09-29T11:33:58","slug":"born-umbilical-blood-to-transfuse-preterm-neonates","status":"publish","type":"kf_gem_progetto","link":"https:\/\/gemelligenerator.it\/it\/progetti\/born-umbilical-blood-to-transfuse-preterm-neonates\/","title":{"rendered":"BORN (umBilical blOod to tRansfuse preterm Neonates)"},"content":{"rendered":"\n<p><strong>Principal investigator<\/strong>: Prof. Luciana Teofili &#8211; \u00a0Medicina Trasfusionale, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica, ed Ematologia;<\/p>\n\n\n\n<p><strong>Co-Principal Investigator<\/strong>: Prof. Patrizia Papacci &#8211; Neonatologia, Dipartimento per le Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica. Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy<\/p>\n\n\n\n<p><strong>In collaborazione con:<\/strong> Tina Pasciuto, Iolanda Mozzetta, Gabriele Placidi, Paolo Casu &#8211; Data Collection; Fernando Palluzzi, Luciano Giaco\u2019 &#8211; Bioinformatics<\/p>\n\n\n\n<p><strong>Promosso da <\/strong>Fondazione Policlinico A. Gemelli IRCSS, con il supporto della Fresenius HemoCare.<\/p>\n\n\n\n<p><strong>Registrato a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/\">https:\/\/clinicaltrials.gov\/<\/a> ; identificativo NCT05100212.<\/p>\n\n\n\n<p>I neonati di et\u00e0 gestazionale estremamente bassa (cio\u00e8 nati prima delle 28 settimane di gestazione) necessitano di ripetute trasfusioni di concentrati di globuli rossi, abitualmente ottenuti da donatori adulti (A-RBC). Numerosi studi hanno evidenziato che le ripetute trasfusioni sono associate ad un alto rischio di mortalit\u00e0 e morbilit\u00e0. Osservazioni recenti hanno mostrato una stretta associazione tra bassi livelli di emoglobina fetale (HbF) e gravit\u00e0 della retinopatia del prematuro (ROP) e della displasia broncopolmonare (BPD), suggerendo che l&#8217;effetto dannoso delle trasfusioni \u00e8 mediato dalla progressiva perdita di HbF nei piccoli pazienti. In un precedente studio pilota il nostro gruppo ha dimostrato che &nbsp;le trasfusioni di globuli rossi ottenute da sangue di cordone ombelicale (CB-RBC) mantengono l&#8217;HbF a livelli significativamente pi\u00f9 elevati rispetto a quelli osservati dopo A-RBC, potenzialmente prevenendo o riducendo la gravit\u00e0 di ROP e BPD.<\/p>\n\n\n\n<p>Lo studio BORN arruola neonati prematuri, con l&#8217;obiettivo di testare l&#8217;efficacia di questa innovativa pratica trasfusionale con CB-RBC rispetto alle trasfusioni standard nel ridurre l&#8217;incidenza di forme severe di ROP. BORN mira anche ad identificare il livello ottimale di HbF per prevenire le forme severe di \u00a0ROP e ridurre la gravit\u00e0 di altre malattie associate alla prematurit\u00e0.<br><\/p>\n\n\n\n<p><strong>Study sites.<\/strong> BORN \u00e8 uno studio italiano multicentrico attualmente in corso, che coinvolge le banche del sangue cordonale e le unit\u00e0 di terapia intensiva neonatale.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"503\" class=\"wp-image-5365\" style=\"width: 650px;\" src=\"http:\/\/www.gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-scaled.jpg\" alt=\"\" srcset=\"https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-scaled.jpg 2560w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-300x232.jpg 300w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-1024x793.jpg 1024w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-768x595.jpg 768w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-1536x1189.jpg 1536w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/Figre-2-Trial-2048x1585.jpg 2048w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"310\" class=\"wp-image-5393\" style=\"width: 700px;\" src=\"http:\/\/www.gemelligenerator.it\/wp-content\/uploads\/2022\/04\/I-nostri-donatori.jpg\" alt=\"\" srcset=\"https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/I-nostri-donatori.jpg 841w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/I-nostri-donatori-300x133.jpg 300w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/I-nostri-donatori-768x341.jpg 768w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"348\" class=\"wp-image-5397\" style=\"width: 700px;\" src=\"http:\/\/www.gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-prodotti.jpg\" alt=\"\" srcset=\"https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-prodotti.jpg 828w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-prodotti-300x149.jpg 300w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-prodotti-768x382.jpg 768w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"369\" class=\"wp-image-5395\" style=\"width: 700px;\" src=\"http:\/\/www.gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-pazienti.jpg\" alt=\"\" srcset=\"https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-pazienti.jpg 833w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-pazienti-300x158.jpg 300w, https:\/\/gemelligenerator.it\/wp-content\/uploads\/2022\/04\/i-nostri-pazienti-768x405.jpg 768w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Principal investigator: Prof. Luciana Teofili &#8211; \u00a0Medicina Trasfusionale, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica, ed Ematologia; Co-Principal Investigator: Prof. Patrizia Papacci &#8211; Neonatologia, Dipartimento per le Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica. Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy In collaborazione con: Tina Pasciuto, Iolanda Mozzetta, Gabriele Placidi, [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","kf_gem_progetticat":[],"class_list":{"0":"post-4967","1":"kf_gem_progetto","2":"type-kf_gem_progetto","3":"status-publish","5":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BORN (umBilical blOod to tRansfuse preterm Neonates) - GemelliGenerator<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gemelligenerator.it\/it\/progetti\/born-umbilical-blood-to-transfuse-preterm-neonates\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BORN (umBilical blOod to tRansfuse preterm Neonates) - GemelliGenerator\" \/>\n<meta property=\"og:description\" content=\"Principal investigator: Prof. Luciana Teofili &#8211; \u00a0Medicina Trasfusionale, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica, ed Ematologia; Co-Principal Investigator: Prof. Patrizia Papacci &#8211; Neonatologia, Dipartimento per le Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica. 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