Ricercatori coinvolti:
Luciano Giaco’ PhD
In collaboration with: Unità di Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Obiettivo:
The study’s aim was to investigate the immunohistochemical (IHC) expression of biological markers as potential prognostic/therapeutic factors in vulvar squamous cell carcinoma (VSCC).
Our results support a potential role of immune checkpoint inhibitors and anti-VEGF and anti-EGFR drugs especially in patients with worse prognosis (metastatic, HPV-independent). A panel including EGFR, VEGF, PDL1, p16, and p53 might be performed routinely in primary tumor and repeated in case of lymph node metastases to identify changes in marker expression.
Pubblicazioni:
The Vulvar Immunohistochemical Panel (VIP) Project: Molecular Profiles of Vulvar Squamous Cell Carcinoma.
by Giorgia Garganese, Frediano Inzani, Simona Maria Fragomeni, Giulia Mantovani, Luigi Della Corte, Alessia Piermattei Angela Santoro Giuseppe Angelico, Luciano Giacò, Giacomo Corrado, Anna Fagotti, Gian Franco Zannoni, Giovanni Scambia
Cancers 2021, 13(24), 6373; https://doi.org/10.3390/cancers13246373