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Home / Facilities / Bioinformatics

Bioinformatics

Research projects based on high performance computing in the laboratory by sequencing and integration of multi-omics data (genomics, transcriptomics, proteomics, metabolomics) experiments.
Head: Luciano Giacò, PhD
Email: bioinformatics@www.gemelligenerator.it
Description

The Bioinformatics facility works in strong connection with other “wet lab” facilities of the Gemelli Science Technology Park (GSTeP), which enable to evaluate and identify the best experimental designs to optimize analysis of the previously produced data.

The Bioinformatics facility offers both standard and customized analysis solutions, specifically created for the needs of a research project.

Using a high-performance computational cluster, various research activities are conducted in parallel to complete, in the shortest possible time, high-quality bioinformatics analyzes on a variety of high-throughput experimental data, for example data produced with Next Generation Sequencing techniques like genome, exome, and transcriptome analysis.

Finally, the facility offers computational biochemistry and biophysics analyzes (e.g., drug design studies, molecular dynamics simulations).

Services of Bioinformatics
Secondary Analysis

Secondary Analysis

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Licensing Software

Licensing Software

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NGS Analysis

NGS Analysis

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Dataset upload to the online repository

Dataset upload to the online repository

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Consulting

Consulting

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Projects
A Computational Framework for Comprehensive Genomic Profiling in Solid Cancers: The Analytical Performance of a High-Throughput Assay for Small and Copy Number Variants
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Bioinformatics: From NGS Data to Biological Complexity in Variant Detection and Oncological Clinical Practice
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BORN (umBilical blOod to tRansfuse preterm Neonates)
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Deep Interpreter of Vus Effect - DIVE
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Evaluating the Risk of Inguinal Lymph Node Metastases before Surgery Using the Morphonode Predictive Model: A Prospective Diagnostic Study in Vulvar Cancer Patients
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Identification by Exome Sequencing of Predisposing Variants in Familial Cases of Autoinflammatory Recurrent Fevers
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Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients
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Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center
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Morphonode Predictive Model
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MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
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Noncanonical splicing in medulloblastoma onset and progression
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Palmitoyl
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Predictive biomarkers of chemoradiotherapy response in cervical cancer
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STRuctural stAbility complex and anTIBODY effectiveness against Spike SARS-CoV-2 protein - STRATIBODY
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The impact of the COVID-19 pandemic on oncological disease extent at FDG PET/CT staging: the ONCOVIPET study
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The vulvar immunohistochemical panel (Vip) project: Molecular profiles of vulvar squamous cell carcinoma
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TOC-1
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Unexpected finding of a rare pathogenic germline BRCA1 variant in an intrahepatic cholangiocarcinoma using the Oncomine Focus DNA assay: clinical and diagnostic implications
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Vulvar immunohistochemical panel (VIP) project: molecular profiles of vulvar Paget’s disease
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Team
Luciano Giacò, PhD
Head
Lorenzo De Marco, MSc
Bioinformatician
Giulia Mantini, MSc, PhD
Bioinformatician
Chiara Notturno Granieri, MSc
Bioinformatician
Chiara Parrillo, MSc
Bioinformatician
Federica Persiani, MSc
Bioinformatician
Elisa Pierini BSc
Bioinformatician
Alessia Preziosi, BSc
Bioinformatician
Simone Rossi MSc
Bioinformatician

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